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Why make JEVTANA your next step?

JEVTANA has been proven to help men live longer

JEVTANA is an infusion medicine that was developed specifically to help men with advanced prostate cancer live longer. It is used as a treatment once the cancer has worsened (progressed) following other anti-cancer medicines, including docetaxel.

JEVTANA has been helping men combat advanced prostate cancer since 2010 and is recommended as a treatment following progression on docetaxel by the National Comprehensive Cancer Network (NCCN) based on a high-level of medical evidence.

travels through the body and attacks cells that divide quickly, including cancer cells.

Extends Survival

EXTENDS SURVIVAL

JEVTANA may help you to live longer by reducing your risk of death.

Shrinks Tumors

SHRINKS TUMORS

JEVTANA may slow the growth of your cancer by shrinking tumors.

Works when Docetaxel doesn't

WORKS WHEN
DOCETAXEL DOESN’T

JEVTANA may prolong your survival and shrink your tumors even if docetaxel is no longer working.

Talk to your healthcare providers to find out if JEVTANA is right for you. START HERE >

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What is JEVTANA?

JEVTANA is an infusion medicine used with the steroid medicine prednisone to treat men with prostate cancer that has worsened (progressed) after treatment with other anti-cancer medicines, including docetaxel. JEVTANA has a unique chemical structure different from docetaxel.

How does JEVTANA work?

  • JEVTANA attacks rapidly dividing cells, throughout the body, including cancer cells.
  • Every cell in your body contains supporting structures, like a miniature scaffolding.
  • JEVTANA makes the scaffolding in some cancer cells very stiff, so that the cells can no longer grow or divide.
  • Since prostate cancer cells within a single tumor can be highly diverse, some may respond to treatment while others may not.
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How may JEVTANA help?

The effectiveness of JEVTANA was proven in a clinical study of 755 men who:

  • Had prostate cancer that spread to other parts of the body
  • Were no longer responding to a medical or surgical treatment to lower their testosterone
  • Had previously received treatment with docetaxel, a type of anti-cancer infusion medicine

In the clinical study, JEVTANA was shown to improve overall survival in men:

reduced

vs mitoxantrone

The number of deaths were 234 (62%) out of 378 patients with JEVTANA and 279 (74%) out of 377 patients with mitoxantrone

prolonged

vs 12.7 months with mitoxantrone

shrunk

14.4% vs 4.4% with mitoxantrone

The median overall survival is the length of time from either the date of diagnosis or the start of treatment for a disease, such as cancer, that half of the patients in a group of patients diagnosed with the disease are still alive. (National Cancer Institute: NCI Dictionary of Cancer Terms. Bethesda, MD: National Cancer Institute, 2013. Available at www.cancer.gov/dictionary. Accessed 11/1/16.)

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What are possible side effects?

Common side effects of JEVTANA include:

  • Fever
  • Tiredness
  • Nausea
  • Constipation
  • Weakness
  • Back pain
  • Shortness of breath
  • Cough
  • Joint pain
  • Hair loss
  • Stomach (abdominal) pain
  • Change in your sense of taste
  • Numbness, tingling, burning, or decreased sensation in your hands or feet
  • Blood in the urine. Tell your healthcare providers or nurse if you see blood in your urine
  • Low red blood cell count (anemia): is common with JEVTANA, but can sometimes also be serious. Your healthcare providers will regularly check your red blood cell count. Symptoms of anemia include shortness of breath and tiredness
  • Low platelet count: is common with JEVTANA, but can sometimes also be serious. Tell your healthcare providers if you have any unusual bruising or bleeding
  • Decreased appetite

These are not all the possible side effects of JEVTANA. For more information, ask your
healthcare provider or pharmacist. You may report side effects to FDA at 1-800-FDA-1088.

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Is your disease
progressing and docetaxel
is no longer working?

Talk to your healthcare providers
to find out if JEVTANA is right for you.

See page 16 of your brochure for a list of questions
to ask your healthcare providers. DOWNLOAD HERE >

Download your brochure to see if JEVTANA is right for you >
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Important Safety Information

What is the most important information I should know about JEVTANA?

JEVTANA may cause serious side effects, including: low white blood cells which can cause you to get serious infections, and may lead to death. People who are 65 years or older may be more likely to have these problems. Your healthcare provider:

Tell your healthcare provider right away if you have any of these symptoms of infection during treatment with JEVTANA: fever (take your temperature often during treatment with JEVTANA), cough, burning on urination, muscle aches.

Also, tell your healthcare provider if you have any diarrhea during the time that your white blood cell count is low. Your healthcare provider may prescribe treatment for you as needed.

Severe allergic reactions can happen within a few minutes after your infusion of JEVTANA starts, especially during the first and second infusions. Your healthcare provider should prescribe medicines before each infusion to help prevent severe allergic reactions.

Tell your healthcare provider or nurse right away if you have any of these symptoms of a severe allergic reaction during or soon after an infusion of JEVTANA: rash or itching, skin redness, feeling dizzy or faint, breathing problems, chest or throat tightness, swelling of face.

JEVTANA can cause severe stomach and intestine (gastrointestinal) problems, which may lead to death. You may need to go to the hospital for treatment.

Vomiting and diarrhea can happen when you receive JEVTANA. Severe vomiting and diarrhea with JEVTANA can lead to loss of too much body fluid (dehydration), or too much of your body salts (electrolytes). Death has happened from having severe diarrhea and losing too much body fluid or body salts with JEVTANA. Your healthcare provider will prescribe medicines to prevent or treat vomiting and diarrhea, as needed with JEVTANA.

Tell your healthcare provider if you have vomiting or diarrhea, and/or if your symptoms get worse or do not get better.

JEVTANA can cause a leak in the stomach or intestine, intestinal blockage, infection, and bleeding in the stomach or intestine. This can lead to death. Tell your healthcare provider if you get any of these symptoms: severe stomach-area (abdomen) pain, constipation, fever, blood in your stool or changes in the color of your stool.

Kidney failure may happen with JEVTANA, because of severe infection, loss of too much body fluid (dehydration), and other reasons, which may lead to death. Your healthcare provider will check you for this problem and treat you if needed.

Tell your healthcare provider if you develop these signs or symptoms: swelling of your face or body, decrease in the amount of urine that your body makes each day.

Lung or breathing problems may happen with JEVTANA and may lead to death. People who have lung disease before receiving JEVTANA may have a higher risk for developing lung or breathing problems with JEVTANA treatment. Your healthcare provider will check you for this problem and treat you if needed.

Tell your healthcare provider right away if you develop any new or worsening symptoms, including: trouble breathing, shortness of breath, chest pain, cough, or fever.

Who should not receive JEVTANA Injection?

Do not receive JEVTANA if: your white blood cell (neutrophil count) is too low, you have had a severe allergic reaction to cabazitaxel or other medicines that contain polysorbate 80 (ask your HCP if you are not sure), or you have severe liver problems.

What should I tell my healthcare provider before receiving JEVTANA?

Before receiving JEVTANA, tell your healthcare provider if you: had allergic reactions in the past, have kidney or liver problems, have lung problems, are age 65 or older, have any other medical conditions, are female and

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. JEVTANA can interact with many other medicines. Do not take any new medicines without asking your healthcare provider first. Your healthcare provider will tell you if it is safe to take the new medicine with JEVTANA.

What are the possible side effects of JEVTANA?

Common side effects of JEVTANA include:

  • fever
  • tiredness
  • nausea
  • constipation
  • weakness
  • blood in your urine. Tell your healthcare provider
    or nurse if you see blood in your urine.
  • back pain
  • numbness, tingling, burning or decreased
    sensation in your hands or feet
  • shortness of breath
  • stomach (abdominal) pain
  • change in your sense of taste
  • cough
  • joint pain
  • hair loss
  • decreased appetite

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of JEVTANA. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Please click here for full Prescribing Information, including boxed WARNING.

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